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주요제품

Dharmacon™  >  shRNA Screening Libraries

shRNA Screening Libraries

RNAi Screening Libraries

제품용도 유전자 발현억제 (knockdown)
브랜드 Dharmacon™
개요 shRNA Screening Libraries
제품특징

GIPZ Lentiviral shRNA Libraries

Choose from GIPZ whole genome or gene family libraries for human or mouse. Pre-defined libraries have been assembled using innovative bioinformatic tools to reflect the most up-to-date genetic and ontological information. All libraries are offered as glycerol stocks of shRNA clones arrayed in 96-well plates.

TRIPZ Inducible Lentiviral shRNA Libraries

Human gene families and a genome-wide collection available with an inducible promoter for the study of essential gene function.

TRC Lentiviral shRNA Libraries

Choose from TRC whole genome or gene family libraries for human or mouse. Pre-defined libraries have been assembled using innovative bioinformatic tools to reflect the most up-to-date genetic and ontological information. All libraries are offered as glycerol stocks of shRNA clones arrayed in 96-well plates.

Pooled Lentiviral Screening Libraries

Optimized construction of high-quality pools, complete analysis tools, and validated protocols are essential to a successful outcome when screening with pooled lentiviral libraries.

Cherry-pick Clone Libraries

Choose from our predesigned product lines of shRNA and over-expression reagents to build your own custom library.

SMARTvector Lentiviral shRNA Pooled Libraries

The most advanced shRNA screening tool available. Achieve highly effective gene knockdown using our optimized scaffold combined with promoter and reporter flexibility.

Combine the advantages of rationally designed shRNA with selectable promoters and reporters to perform functional screens of hundreds or thousands of shRNAs in dividing and non-dividing cells.

SMARTvector Inducible Lentiviral shRNA Pooled Libraries

Combines the advantages of pooled shRNA screening with the power of an inducible promoter. Choose the best promoter and reporter for the optimal experiment.

Combine the advantages of rationally designed shRNAs and the flexibiltiy of selectable promoters and reporters with the tight control of the Tet-On 3G tetracycline-inducible transactivator for unmatched shRNA expression.

 

 

제품스펙

Predefined shRNA Libraries

HUMAN
(number of genes)
MOUSE
(numberr of genes)
Predefined shRNA Libraries SMARTvector GIPZ TRC SMARTvector GIPZ TRC
Genome 19,241 18,205 16,111 21,745 18,045 16,008
Druggable Genome 7,341 7,494 7,349 9,723 6,332 6,800
G Protein-Coupled Receptors(GPCR) 377 382 549 494 1041 1029
Ion Channel 340 347 332
Phosphatase 245 254 164 268 123 125
Protease 466 478 529
Protein Kinase 702 709 781 697 713 734
Ubiquitin Coinjugation 557 570 145 511 104
주요사항

GIPZ Lentiviral shRNA Libraries Benefits

• Designed for increased specificity, less toxicity

• TurboGFP marks cells expressing shRNA

• Efficient low copy knockdown

• Genome-wide human and mouse coverage

• Perform efficient RNAi in primary and non-dividing cells

• Guaranteed* knockdown

 

TRC Lentiviral shRNA Libraries Benefits

• Cloned into lentiviral vectors

• Amenable to in vitro and in vivo applications

• Lentiviral vector enables transduction of primary and non-dividing cells

 

Pooled Lentiviral Screening Libraries Features

• Pools of shRNA or microRNA gene families and pathways

• Customizable promoter and reporter options, including inducible promoters

• Complete workflow planning tools and protocols

• Custom human, mouse, and rat libraries available