줄기세포 연구의 모든 것, Stem Cell Marker
2018-11-23
✿ Cell type 별 stem cell marker 종류
Marker Name | Cell Type |
Blood Vessel | |
Fetal liver kinase-1 (Flk1) | Endothelial |
Smooth muscle cell-specific myosin heavy chain | Smooth muscle |
Vascular endothelial cell cadherin | Smooth muscle |
Bone | |
Bone-specific alkaline phosphatase (BAP) | Osteoblast |
Hydroxyapatite | Osteoblast |
Osteocalcin (OC) | Osteoblast |
Bone Marrow and Blood | |
Bone morphogenetic protein receptor (BMPR) | Mesenchymal stem and progenitor cells |
CD4 and CD8 | White blood cell (WBC) |
CD34 | Hematopoietic stem cell (HSC), satellite, endothelial progenitor |
CD34+Sca1+ Lin- profile | Mesencyhmal stem cell (MSC) |
CD38 | Absent on HSC |
CD44 | Mesenchymal |
c-Kit | HSC, MSC |
Colony-forming unit (CFU) | HSC, MSC progenitor |
Fibroblast colony-forming unit (CFU-F) | Bone marrow fibroblast |
Hoechst dye | Absent on HSC |
Leukocyte common antigen (CD45) | WBC |
Lineage surface antigen (Lin) | HSC, MSC |
Differentiated RBC and WBC lineages | |
Mac-1 | WBC |
Muc-18 (CD146) | Bone marrow fibroblasts, endothelial |
Stem cell antigen (Sca-1) | HSC, MSC |
Stro-1 antigen | Stromal (mesenchymal) precursor cells, hematopoietic cells |
Thy-1 | HSC, MSC |
Cartilage | |
Collagen types II and IV | Chondrocyte |
Keratin | Keratinocyte |
Sulfated proteoglycan | Chondrocyte |
Fat | |
Adipocyte lipid-binding protein (ALBP) | Adipocyte |
Fatty acid transporter (FAT) | Adipocyte |
Adipocyte lipid-binding protein (ALBP) | Adipocyte |
General | |
Y chromosome | Male cells |
Karyotype | Most cell types |
Liver | |
Albumin | Hepatocyte |
B-1 integrin | Hepatocyte |
Pluripotent Stem Cells | |
Alkaline phosphatase | Embryonic stem (ES), embryonal carcinoma (EC) |
Alpha-fetoprotein (AFP) | Endoderm |
Bone morphogenetic protein-4 | Mesoderm |
Brachyury | Mesoderm |
Cluster designation 30 (CD30) | ES, EC |
Cripto (TDGF-1) | ES, cardiomyocyte |
GATA-4 gene | Endoderm |
GCTM-2 | ES, EC |
Genesis | ES, EC |
Germ cell nuclear factor | ES, EC |
Hepatocyte nuclear factor-4 (HNF-4) | Endoderm |
Nestin | Ectoderm, neural and pancreatic progenitor |
Neuronal cell-adhesion molecule (N-CAM) | Ectoderm |
OCT4/POU5F1 | ES, EC |
Pax6 | Ectoderm |
Stage-specific embryonic antigen-3 (SSEA-3) | ES, EC |
Stage-specific embryonic antigen-4 (SSEA-4) | ES, EC |
Stem cell factor (SCF or c-Kit ligand) | ES, EC, HSC, MSC |
Telomerase | ES, EC |
TRA-1-60 | ES, EC |
TRA-1-81 | ES, EC |
Vimentin | Ectoderm, neural and pancreatic progenitor |
Skeletal Muscle/Cardiac/Smooth Muscle | |
MyoD and Pax7 | Myoblast, myocyte |
Myogenin and MR4 | Skeletal myocyte |
Myosin heavy chain | Cardiomyocyte |
Myosin light chain | Skeletal myocyte |