줄기세포 연구의 모든 것, 3D Culture

2018-11-16

3D culture란?

생체 내와 같은 입체적인 환경을 조성해 주어 세포 본래의 특성이 재현되도록 하는 세포 배양법

3D culture의 필요성

2D vs. 3D Culture

2D Cell Culture

3D Cell Culture

Advantages

• Well established for primary assessment

• Economical

• Easy and convenient for the analysis set up

• High throughput capacity: feasible

• Substrates mimic the natural extracellular matrix

• Mimic the in vivo microenvironment, as well as cell-cell and cell-matrix interaction

• Enable the assessment of tissue penetration ability and bystander killing efficiency of drugs, as well as the drug resistance of cells.

• Low design-in vitro-in vivo-redesign requirement: reduce overall cost for the pre-clinical in vivo test

Disadvantages

• Lack cell-cell & cell-matrix interaction information

• Unable to mimic in vivo microenvironment

• Homogenous drug distribution

• Unable to assess the tissue penetration ability and bystander killing efficiency of drugs or the drug resistance of cells

• Relatively low throughput capacity

• More expensive and laborious for the establishment of culture models and set-up of analyzing experiments

3D culture plate 제품 소개

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